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KMID : 0352720000240020079
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Journal of Ginseng Research
2000 Volume.24 No. 2 p.79 ~ p.82
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Ginseng Saponin Prevents the LPS-induced TNF-α Production in Mice
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Dong Hwan Sohn/Kyoung Mi Kim
Hye Ju Kim/Jae Ha Ryu/Dong Hwan Sohn
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Abstract
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Saponins, the major component of ginseng root, mediate the pharmacological action of the ginseng. It has been reported that ginseng roots have protective effect against various toxins. In this study, the effects of ginseng total saponin (GTS) on tumor necrosis factor-alpha (TNF-α) production induced by bacterial toxin was investigated. TNF-α level in lipopolysaccharides (LPS)-activated serum was remarkably reduced by intraperitoneal administration (50 mg/kg)of ginseng total saponin (GTS) into mice. The inhibitory effect against TNF-α production was not significant when GTS was given after the LPS injection, and by oral administration. These results suggested that ginseng root may have protective activity against liver damage accompanying the overproduction of TNF-α and GTS is the active component of ginseng.
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KEYWORD
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Ginseng, Saponin, tumor necrosis factor (TNF-α),
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